BioSolution Designs
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SYNTHETIC BIOLOGY INVENTION STUDIO • BOULDER, CO OPERATIONAL

THINK MULTIGENIC®

Complex Biological Problems Require MULTIGENIC Solutions™

Save Lives. Create Jobs. Heal Our Planet.
Applying Multigenic Synthetic Biology Across Medicine, Food, and the Environment

Advanced Therapies require Coordinated, Multi-Modal, Multi-Effector Therapeutic Networks

01 // RAPTOR ENABLES

RAPTOR OS™

BioSolution Designs’ Integrated Technologies

Raptor OS is BioSolution Designs’ integrated technology operating system for the development of paradigm shifting advanced therapies that are large (>10kb), complex, and / or encode multiple active therapeutic effectors (multigenic). It brings together five coordinated technology pillars—Gene Delivery, Genome Context, Gene Expression, Effector Engineering, and BioManufacturing—so therapeutic programs can be designed, controlled, and translated within a single modular architecture.

Pillar 01: Gene Delivery
Non-Viral Delivery

LAVNAV

Large Cargo Viral

MEGA

RNA & Protein Delivery

ENGINEERED EXOSOMES

High-Capacity Vectorization
Pillar 02: Genome Context
Genome Integration

INTEGRASE

Genome Modification

BoP NUCLEASE

Directed Positioning

MATS™

Site-Specific Insertion
Pillar 03: Gene Expression
Transcription Controller

TRANSCRIPTION UNIT

Inducible Systems

SWITCH

Epigenetic Insulation

CHROMATIN BOUNDARIES

Tunable Expression Control
Pillar 04: Effector Engineering
Disease-Specific Effectors

NOVEL

Full-Length Proteins

OPTIMIZED (COL7A1)

Structural Integrity

HOMOTRIMER ASSEMBLY

Large Cargo Structural Design
Pillar 05: BioManufacturing
ccDNA Vector Synthesis

BoP MULTIGENE MFG

Affinity Capture & Beads

RAPTOR BINDER BEADS

Host Cell Production

IMMORTAL CELLS

Plasmid-Free Scalable Footprint
FOUNDATION LAYER ANCHOR

Enabled by Bird of Prey (BoP®) Complex DNA Design and Assembly Technology

BioSolution Designs • Boulder, CO
02 // BATS

BSD Advanced Therapies Syndicate (BATS)

BSD companies employ RAPTOR OS to generate Discovery Systems and Products

BioSolution Designs is an intellectual property holding company and invention studio. RAPTOR OS grants each company licensed access to a subset of BSD technologies and services.

Discovery Systems
OspreyBioRUO Discovery BioToolsWebsite coming soon
BioManufacturing
CONDORVenture StudioBioManufacturing ServicesWebsite coming soon
Advanced Therapies
MULTIGENIXVenture Studio & FIPCOEngineered Multigenic & Polygenic Cell SystemsWebsite coming soon
IntegriGenVIPCORare Skin Disease Therapiesintegrigen.bio ↗
PEREGRINEVIPCOGM-DC Cancer TherapiesWebsite coming soon
FALCONVenture Studio & FIPCOIn-Vivo Gene Delivery PlatformsWebsite coming soon
BeatBioVIPCOCardiovascular TherapiesWebsite coming soon

FIPCO — fully integrated pharmaceutical company. VIPCO — virtually integrated pharmaceutical company. The syndicate will grow over time.

03 // LEADERSHIP & GOVERNANCE

Team

04 // THE ONE HEALTH FOUNDATION

One Health Invention Studio

Save Lives. Create Jobs. Heal Our Planet.

BioSolution Designs, Inc. is an advanced synthetic biology invention studio and intellectual property holding company based in Boulder, Colorado. Guided by more than twenty-five years’ experience in biotechnology platform invention and clinical translation, we design, engineer, and develop complex, multi-kilobase biological operating systems that solve intractable challenges across the One Health continuum.

TRIAD 01 // MEDICINE

Advanced Therapies

TRIAD 02 // FOOD

Food

TRIAD 03 // ENVIRONMENT

Environment